Viagra - Does Viagra work? – A dilemma answered in brighter lights
The degree of efficacy in Viagra has always been a topic of discussion – not only among the 40-up men but also amongst young adults who have started to see dating from whole new angles. Dilemmas often lead such inquisitive minds into quandaries making extraction difficult. So, let’s understand Viagra’s chief mechanism of action that’s responsible to fight male impotence.
Sildenafil, the chief constituent of Viagra, enhances the effects of NO (nitric oxide) that parasympathetic nerves release in the corpus cavernosum (the expandable tissues) of the penis. The NO and soluble guanylate cyclase (sGC) then interacts with sGC, elevating cGMP levels.
It’s the NO/cGMP pathway that’s specifically targeted by any Sildenafil comprising medication. Sildenafil inhibits selectively phosphodiesterase 5 (PDE5), an enzyme that breaks down cGMP, whose intracellular concentration determines the necessary levels for mediating vasodilatation, augmenting consequently the erectile function.
Another question that often bugs men is: Does Viagra work with alcohol? Yes and no; Sildenafil, in conjunction with alcohol may result in a stalemate situation because alcohol is primarily a depressant; however, with social amounts of alcohol, Sildenafil has not been known to produce any drastic results. Large quantities of alcohol may intensify the side effects and being detrimental to the gut mucosa, might give rise to severe diarrhea or other stomach disorders. However, Sildenafil’s power to amplify endogenic nitric oxide effects has been found to prevent gastropathy induced by several non-steroidal anti-inflammatory drugs (besides alcohol); Sildenafil reduces leukocytes from adhering and maintain a healthy gastric blood circulation. Sildenafil is a potent curing agent for gastric haemorrhagic damages brought forth by ethanol; it also fights edema and epithelial cell loss.
Does Viagra work for women? Pfizer Inc led a research and found mostly positive and beneficial results in women who are either past the menopause or has had undergone a hysterectomy. These women were receiving HRT (hormone replacement therapy) and were between 30 years and 71 years of age.
Those with FSAD (Female Sexual Arousal Disorder) were benefited the most with the use of Viagra, followed by women with HSDD (Hypoactive Sexual Desire Disorder) without any sort of underlying problems on emotional or psychological grounds.
To answer how Viagra works in this case, it is the same mechanism of action in males that’s assumed to stay responsible; it is the same enzyme inhibitor that influences in women an enhanced pelvic blood flow. However, since it has been proven that genital arousal alone cannot trigger sexual desire in women, something thus must come up which will also have effects in women’s mental and emotional grounds. That is the idea behind the true Women’s Viagra and since Pfizer has now put an entire team of researchers on the job, we may expect a revolution in the whole A-pill-for-everything concept.
