Cialis - Everything you wanted to know about Cialis
Cialis is a drug which is used for the treatment of erectile dysfunction (ED). Cialis is actually the market name for the drug called Tadalafil, which is approved by the FDA in 2003. Tadalafil belongs to the PDE5 or the phosphodiesterase type 5 inhibitors. This drug was the first active oral treatment for erectile dysfunction. Other uses of this drug include the management of pulmonary hypertension. Cialis, in medical terms is a selective inhibitor of cGMP-PDE5 or cyclic quinidine monophosphate – phosphodiesterase type 5.
A very frequent and common question asked is does Cialis work? Well, Cialis works for almost everybody. All over the world over 8 million men have undergone clinical trials. A very high success rate has been registered.
Working of Cialis
If you are wondering how does Cialis work, then here is your answer. How Cialis works is a complicated process. Cialis is a PDE5 pharmacological inhibitor which works by dilating the blood vessels and increasing the blood flow to the penis. The arteries in the penis and smooth muscle of corpus cavernosum are relaxed as a result of Cialis. The discharge of nitric oxide from the endothelial cells and the nerve terminals mediates this process. This nitric oxide helps in the production of cGMP in those muscle cells. The cGMP relaxes these muscles thereby increasing the blood flowing to the corpus cavernosum. The PDE5 inhibition improves the erection by raising the quantity of cGMP. Because the discharge of NO by the nerve terminals can only happen if there is stimulation of penis, the drug Cialis has no influence without arousal. In simple terms, the Tadalafil blocks the chemicals that are generated after a sexual intercourse. These chemicals actually help the penis to get back to its flaccid state. These drugs block its action and ensure that the penis stays harder for a long time.
Cialis unlike its competitors (Viagra and Levitra) has a longer lasting effect. While both Viagra and Levitra last for about 5 hours after dosage, Cialis goes on for one and a half day. Due to such a long activity period, Cialis is called the “weekend pill”. This doesn’t mean that the penis will stay erect 36 hours. Men who take Cialis are under its effect for 36 hours. All they need is some stimulation and they are back in action. Cialis is also different from Viagra ad Levitra in another way. Physical stimulation of the penis is necessary for Cialis to show its effect. Without any sexual stimulation, Cialis has no effect.
Side Effects of Cialis
Now that we are clear about how Cialis works on men, let us look into the side effects of the use of Cialis. Like any other artificial drug, Cialis also has some side effects. The side effects are usually short term effects. They include headache, dyspepsia, back pain, runny nose, muscle aches, etc. A few hours later, these side effects disappear. However, body aches and back pain may last for about 2 days. Cialis should be taken only under medical prescription. The complete knowledge of how Cialis works and its side effects should be there, when taking Cialis. It causes the blood pressure to drop suddenly and sometimes leave you dizzy. Cialis should not be taken when you are under prescription of nitrates. Your penis will remain erect if you take Cialis along with nitrates. Cialis should also be avoided when you are under prescription for alpha-blockers. Telling your doctor about your medical history will help you stay away from the side effects of Cialis.
If you are wondering does Cialis work for women, then let me tell you it hasn’t been approved by the Food and Drug Authority yet. Many clinical trials have been carried out about the reaction Cialis has on women, but its safety isn’t proved. So it is highly recommended that Cialis should not be taken by women.
